This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to
Generate Epilepsy?: Neuron Skip to Main Content Skip to Main Menu Advertisement …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Gap junctions play an important role in brain physiology. They synchronize neuronal activity
and connect glial cells participating in the regulation of brain metabolism and homeostasis …

The level of electrotonic coupling in the inferior olive is extremely high, but its functional role
in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary …

Background: Gap junctions are clusters of intercellular channels allowing the bidirectional
pass of ions directly into the cytoplasm of adjacent cells. Electrical coupling mediated by gap …

The WAG/Rij rat model has recently gathered attention as a suitable animal model of
absence epileptogenesis. This latter term has a broad definition encompassing any possible …

Gap junctions (GJs) are expressed in most cell types of the nervous system, including
neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier …

Several signaling pathways are believed to be involved in the epileptogenic process that
triggers the subsequent changes in the brain causing epilepsy. The mammalian target of …

This article represents a synthesis of presentations made by the authors during a scientific
meeting held in London on 7 June 2010 and organized by GlaxoSmithKline. Each speaker …