Control of metastasis by NK cells
The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly
accepted as a core component of carcinoma progression. Collectively, EMT and …
accepted as a core component of carcinoma progression. Collectively, EMT and …
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
MM Berrien-Elliott, JA Foltz… - Science translational …, 2022 - science.org
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
C Yang, JR Siebert, R Burns, ZJ Gerbec… - Nature …, 2019 - nature.com
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
[HTML][HTML] Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the
key events controlling TRM cell development is the local retention of TRM cell precursors …
key events controlling TRM cell development is the local retention of TRM cell precursors …
A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of
cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that …
cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that …
MEF2C regulates NK cell effector functions through control of lipid metabolism
JH Li, A Zhou, CD Lee, SN Shah, JH Ji… - Nature …, 2024 - nature.com
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare
mutations in a small subset of transcription factors can result in decreased NK cell numbers …
mutations in a small subset of transcription factors can result in decreased NK cell numbers …
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling
Among the features that distinguish type 1 innate lymphoid cells (ILC1s) from natural killer
(NK) cells is a gene signature indicative of'imprinting'by cytokines of the TGF-β family. We …
(NK) cells is a gene signature indicative of'imprinting'by cytokines of the TGF-β family. We …
Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
Efficiency and target derepression of anti-miR-92a: results of a first in human study
MicroRNA (miRNA) inhibition is a promising therapeutic strategy in several disease
indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets …
indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets …