The mercurial nature of neutrophils: still an enigma in ARDS?

AE Williams, RC Chambers - American Journal of …, 2014 - journals.physiology.org
The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

Interleukin 8 and acute lung injury

TC Allen, A Kurdowska - Archives of Pathology and …, 2014 - meridian.allenpress.com
Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular
damage, and increased pulmonary vascular and epithelial permeability, frequently resulting …

MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I

T **e, J Liang, N Liu, Q Wang, Y Li… - The Journal of …, 2012 - journals.aai.org
The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs
(miRNAs) are crucial biological regulators that act by suppressing their target genes and are …

The influence of IgG density and macrophage Fc (gamma) receptor cross-linking on phagocytosis and IL-10 production

P Gallo, R Gonçalves, DM Mosser - Immunology letters, 2010 - Elsevier
We have previously demonstrated that the addition of immune complexes (IC) to stimulated
macrophages could profoundly influence cytokine production. In the present work we sought …

[HTML][HTML] Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental …

S Jia, H Luo, X Liu, X Fan, Z Huang, S Lu… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Reduning injection (RDNI) is a patented Traditional
Chinese medicine that contains three Chinese herbal medicines, respectively are the dry …

[HTML][HTML] Anti-cytokine autoantibodies in systemic lupus erythematosus

HS Howe, BPL Leung - Cells, 2019 - mdpi.com
Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic
autoimmune disease of considerable heterogeneity. Insights gained about the cytokine …

Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1

JM Florence, A Krupa, LM Booshehri, TC Allen… - PLoS …, 2017 - journals.plos.org
The atherosclerotic process begins when vascular endothelial cells undergo pro-
inflammatory changes such as aberrant activation to dysfunctional phenotypes and …

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury

A Krupa, M Fol, M Rahman, KY Stokes… - … of Physiology-Lung …, 2014 - journals.physiology.org
Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk)
may play an important role in the pathophysiology of local inflammation in acute lung injury …

Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor–4 receptor crosstalk in human neutrophils

A Krupa, R Fudala, JM Florence, T Tucker… - American journal of …, 2013 - atsjournals.org
Previous observations by our laboratory indicate that the presence of anti–IL-8 autoantibody:
IL-8 immune complexes in lung fluids from patients with acute lung injury/acute respiratory …

Growth factors and cytokines in acute lung injury

JC Deng, TJ Standiford - Comprehensive Physiology, 2010 - Wiley Online Library
Cytokines and growth factors play an integral role in the maintenance of immune
homeostasis, the generation of protective immunity, and lung reparative processes …