Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Essential hypertension has devastating effects on the brain, being the major cause of stroke
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …

Background and Purpose—Cerebral autoregulation may become impaired after stroke. To
provide a review of the nature and extent of any autoregulation impairment after stroke and …

Background: Mechanisms underlying the association between age-related arterial stiffening
and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be …

Introduction Postoperative delirium is common in older patients. Despite its prognostic
significance, the pathophysiology is incompletely understood. Although many risk factors …