Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of
Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …

G protein-coupled receptors transduce diverse extracellular signals, such as
neurotransmitters, hormones, chemokines, and sensory stimuli, into intracellular responses …

Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for
the discovery and development of small-molecule therapeutics, it is posited that additional …

The many components of G‐protein‐coupled receptor (GPCR) signal transduction provide
cells with numerous combinations with which to customize their responses to hormones …

Investigators studying G protein–coupled signaling—often called the best-understood
pathway in the world owing to intense research in medical fields—have adopted plants as a …

Transmembrane signals initiated by a broad range of extracellular stimuli converge on
nodes that regulate phospholipase C (PLC)–dependent inositol lipid hydrolysis for signal …

Synaptic plasticity is thought to underlie learning and memory, but the complexity of the
interactions between the ion channels, enzymes and genes that are involved in synaptic …

The regulators of G-protein signaling (RGS) proteins were initially characterized as inhibitors
of signal transduction cascades initiated by G-protein-coupled receptors (GPCR) because of …