Despite effective antiretroviral therapy (ART), people living with HIV (PLWH) still present
persistent chronic immune activation and inflammation. This condition is the result of several …

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Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of
HIV infection. Objective To evaluate new data and treatments and incorporate this …

Background Effective two-drug regimens could decrease long-term drug exposure and
toxicity with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the efficacy …

Objectives In the HIV-1-positive population, a paradigm shift from three-drug regimens
(3DRs) to dolutegravir-based two-drug regimens (2DRs) both as initial and switch treatment …

Introduction: Darunavir (DRV) was the last approved protease inhibitor (PI) and has been
extensively used for the treatment of HIV in both naïve and experienced subjects due to its …

Introduction: Despite the efficacy and safety of antiretroviral therapy, new treatment options
are needed to address the concerns of patients and physicians regarding long-term …

As people live longer with HIV infection, there has been a resurgence of interest in
challenging the use of three-drug therapy, including two nucleoside reverse transcriptase …

Introduction As HIV has become a manageable chronic condition, a renewed and increased
interest in challenging traditional three-drug HIV therapies and moving toward two-drug …

Background Patients who start combination antiretroviral therapy (cART) during primary
human immunodeficiency virus type 1 (HIV-1) infection show a smaller HIV-1 latent …