The Lancet Commission on diabetes: using data to transform diabetes care and patient lives

JCN Chan, LL Lim, NJ Wareham, JE Shaw, TJ Orchard… - The Lancet, 2020 - thelancet.com
Executive summary 2020 will go down in history as the year when the global community was
awakened to the fragility of human health and the interdependence of the ecosystem …

Type 1 diabetes mellitus

A Katsarou, S Gudbjörnsdottir, A Rawshani… - Nature reviews Disease …, 2017 - nature.com
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012

EJ Mayer-Davis, JM Lawrence… - … England Journal of …, 2017 - Mass Medical Soc
Background Diagnoses of type 1 and type 2 diabetes in youths present a substantial clinical
and public health burden. The prevalence of these diseases increased in the 2001–2009 …

The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

[HTML][HTML] ISPAD Clinical Practice Consensus Guidelines 2018: Definition, epidemiology, and classification of diabetes in children and adolescents

EJ Mayer-Davis, AR Kahkoska, C Jefferies… - Pediatric …, 2018 - ncbi.nlm.nih.gov
• Diagnostic criteria for all types of diabetes in children and adolescents are based on
laboratory measurement of plasma blood glucose levels (BGL) and the presence or …

Type 1 diabetes

MA Atkinson, GS Eisenbarth, AW Michels - The lancet, 2014 - thelancet.com
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas

P Saeedi, I Petersohn, P Salpea, B Malanda… - Diabetes research and …, 2019 - Elsevier
Aims To provide global estimates of diabetes prevalence for 2019 and projections for 2030
and 2045. Methods A total of 255 high-quality data sources, published between 1990 and …

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

JGM Markle, DN Frank, S Mortin-Toth, CE Robertson… - Science, 2013 - science.org
Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many
of which are more prevalent in women. We demonstrate that early-life microbial exposures …

Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989–2013: a multicentre prospective …

CC Patterson, V Harjutsalo, J Rosenbauer, A Neu… - Diabetologia, 2019 - Springer
Aims/hypothesis Against a background of a near-universally increasing incidence of
childhood type 1 diabetes, recent reports from some countries suggest a slowing in this …

The use of animal models in diabetes research

AJF King - British journal of pharmacology, 2012 - Wiley Online Library
Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …