Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

L Klingelhoefer, H Reichmann - Nature Reviews Neurology, 2015 - nature.com
Parkinson disease (PD) follows a defined clinical pattern, and a range of nonmotor
symptoms precede the motor phase. The predominant early nonmotor manifestations are …

Chronic diseases, inflammation, and spices: how are they linked?

AB Kunnumakkara, BL Sailo, K Banik, C Harsha… - Journal of translational …, 2018 - Springer
Extensive research within the last several decades has revealed that the major risk factors
for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental …

Revisiting an ancient spice with medicinal purposes: Cinnamon

R Ribeiro-Santos, M Andrade, D Madella… - Trends in Food Science …, 2017 - Elsevier
Background Cinnamon is used as a spice and an aromatic plant. Their leaves and bark are
used as source of cinnamon oil. Cinnamon belongs to the Lauraceae family. Scope and …

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

PK Mukherjee, T Efferth, B Das, A Kar, S Ghosh… - Phytomedicine, 2022 - Elsevier
Background The worldwide corona virus disease outbreak, generally known as COVID-19
pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission …

Inhibition by multifunctional magnetic nanoparticles loaded with alpha-synuclein RNAi plasmid in a Parkinson's disease model

S Niu, LK Zhang, L Zhang, S Zhuang, X Zhan… - …, 2017 - pmc.ncbi.nlm.nih.gov
Lewy bodies are considered as the main pathological characteristics of Parkinson's disease
(PD). The major component of Lewy bodies is α-synuclein (α-syn). The use of gene therapy …

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

H Javed, MF Nagoor Meeran, S Azimullah… - Frontiers in …, 2019 - frontiersin.org
α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

High throughput sequencing identifies microRNAs mediating α-synuclein toxicity by targeting neuroactive-ligand receptor interaction pathway in early stage of …

Y Kong, X Liang, L Liu, D Zhang, C Wan, Z Gan… - PloS one, 2015 - journals.plos.org
Parkinson's disease (PD) is a prevalent neurodegenerative disorder with pathological
features including death of dopaminergic neurons in the substantia nigra and intraneuronal …

Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities

E Angelopoulou, YN Paudel, C Piperi… - Journal of biochemical …, 2021 - Wiley Online Library
Parkinson's disease (PD) is the most common neurodegenerative movement disorder with
obscure etiology and no disease‐modifying therapy to date. Hence, novel, safe, and low …

Drosophila melanogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components

K Panchal, AK Tiwari - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Plants/plant-derived components have been used from ancient times to treat/cure several
human diseases. Plants and their parts possess several chemical components that play the …

Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells

E Ramazani, M YazdFazeli, SA Emami… - Molecular biology …, 2020 - Springer
Cinnamon (Cinnamomum verum and C. cassia) is a medicinal plant, widely-used as a
culinary spice. It possesses various therapeutic effects and can slow down the progression …