Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
ROS1-dependent cancers—biology, diagnostics and therapeutics
The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …
A single-cell transcriptome atlas profiles early organogenesis in human embryos
The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
AnimalTFDB 4.0: a comprehensive animal transcription factor database updated with variation and expression annotations
WK Shen, SY Chen, ZQ Gan, YZ Zhang… - Nucleic acids …, 2023 - academic.oup.com
Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
[HTML][HTML] GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
Pediatric cancers often mimic fetal tissues and express proteins normally silenced
postnatally that could serve as immune targets. We developed T cells expressing chimeric …
postnatally that could serve as immune targets. We developed T cells expressing chimeric …
Principles and challenges of modeling temporal and spatial omics data
Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …
and spatial dependencies underlying a biological process or system. With advances in high …
Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
The majority of oncogenic drivers are intracellular proteins, thus constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …
Gene set analysis: challenges, opportunities, and future research
Gene set analysis methods are widely used to provide insight into high-throughput gene
expression data. There are many gene set analysis methods available. These methods rely …
expression data. There are many gene set analysis methods available. These methods rely …