Diabetes mellitus and its complications pose a major threat to global health and affect the
quality of life and life expectancy of patients. Currently, the application of traditional …

The successful expansion of hematopoietic stem and progenitor cells (HSPCs) from
umbilical cord blood (UCB) for transplantation could revolutionize clinical practice by …

Hematopoietic stem cells (HSCs) in the bone marrow are able to differentiate into all types of
blood cells and supply the organism each day with billions of fresh cells. They are applied to …

While two-dimensional (2D) monolayers of mesenchymal stem/stromal cells (MSCs) have
been shown to enhance hematopoietic stem/progenitor cell (HSPC) expansion in vitro …

Abstract Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein
that mainly expresses in the liver, and is regulated by numerous post-translational …

Cell dose limits greater use of umbilical cord blood (UCB) in hematopoietic cell
transplantation. The clinical benefits of ex vivo expansion need clarity to understand its …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …

Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human
hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their …

Successful expansion of bone marrow (BM) hematopoietic stem and progenitor cells
(HSPCs) would benefit many HSPC transplantation and gene therapy/editing applications …

Basic and translational research on lung biology has discovered multiple progenitor cell
types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of …