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Antibody drug conjugates for treatment of breast cancer: novel targets and diverse approaches in ADC design
Breast cancer is a heterogeneous group of malignancies with a spectrum of molecular
subtypes, pathologies and outcomes that together comprise the most common non …
subtypes, pathologies and outcomes that together comprise the most common non …
Therapeutic targeting of DNA replication stress in Cancer
L Gu, RJ Hickey, LH Malkas - Genes, 2023 - mdpi.com
This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
[HTML][HTML] Rapid microfluidic preparation of niosomes for targeted drug delivery
Niosomes are non-ionic surfactant-based vesicles with high promise for drug delivery
applications. They can be rapidly prepared via microfluidics, allowing their reproducible …
applications. They can be rapidly prepared via microfluidics, allowing their reproducible …
Development of a highly stable and targetable nanoliposomal formulation of topotecan
Topotecan (TPT), a highly active anticancer camptothecin drug, would benefit from
nanocarrier-mediated site-specific and intracellular delivery because of a labile lactone ring …
nanocarrier-mediated site-specific and intracellular delivery because of a labile lactone ring …
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity
This work describes the synthesis of 1, 2, 3, 4-tetrahydroquinolinylphosphine oxides,
phosphanes and phosphine sulfides as well as that of quinolinylphosphine oxides and …
phosphanes and phosphine sulfides as well as that of quinolinylphosphine oxides and …
Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer
K Hashimoto, S Man, P Xu, W Cruz-Munoz… - Molecular cancer …, 2010 - aacrjournals.org
Low-dose metronomic chemotherapy has shown promising activity in many preclinical and
some phase II clinical studies involving various tumor types. To evaluate further the potential …
some phase II clinical studies involving various tumor types. To evaluate further the potential …
Revisiting the nanoformulation design approach for effective delivery of topotecan in its stable form: an appraisal of its in vitro Behavior and tumor amelioration …
Topotecan (TPT) is indicated against a variety of solid tumors, but has restricted clinical use
owing to associated pharmaceutical caveats. This study is focused at formulating a …
owing to associated pharmaceutical caveats. This study is focused at formulating a …
[HTML][HTML] Formulation and optimization of topotecan nanoparticles: in vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes
The study focuses on widening up the therapeutic perspective of anti-cancer therapy by
entrap** a hydrophilic anticancer drug, topotecan hydrochloride (TOPO) in biodegradable …
entrap** a hydrophilic anticancer drug, topotecan hydrochloride (TOPO) in biodegradable …
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies
Emerging biological and translational insights from large sequencing efforts underscore the
need for genetically-relevant cell lines to study the relationships between genomic …
need for genetically-relevant cell lines to study the relationships between genomic …
Synthesis and biological evaluation of indeno [1, 5] naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity
In an effort to establish new candidates with improved anticancer activity, we report here the
synthesis of various series of 7H-indeno [2, 1-c][1, 5]-naphthyridines and novel 7H-indeno …
synthesis of various series of 7H-indeno [2, 1-c][1, 5]-naphthyridines and novel 7H-indeno …