Chemical reporters for biological discovery
M Grammel, HC Hang - Nature chemical biology, 2013 - nature.com
Functional tools are needed to understand complex biological systems. Here we review how
chemical reporters in conjunction with bioorthogonal labeling methods can be used to …
chemical reporters in conjunction with bioorthogonal labeling methods can be used to …
The Tn antigen—structural simplicity and biological complexity
T Ju, VI Otto, RD Cummings - … Chemie International Edition, 2011 - Wiley Online Library
Glycoproteins in animal cells contain a variety of glycan structures that are added co‐and/or
posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages …
posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages …
Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis: secretion of fibroblast growth factor 23 requires O-glycosylation
K Kato, C Jeanneau, MA Tarp, A Benet-Pages… - Journal of Biological …, 2006 - ASBMB
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is
involved in initiation of O-glycosylation, were recently identified as a cause of the rare …
involved in initiation of O-glycosylation, were recently identified as a cause of the rare …
Site-specific protein O-glycosylation modulates proprotein processing—deciphering specific functions of the large polypeptide GalNAc-transferase gene family
BACKGROUND: Posttranslational modifications (PTMs) greatly expand the function and
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …
Location, location, location: new insights into O-GalNAc protein glycosylation
O-GalNAc glycosylation of proteins confers essential structural, protective and signaling
roles in eumetazoans. Addition of O-glycans onto proteins is an extremely complex process …
roles in eumetazoans. Addition of O-glycans onto proteins is an extremely complex process …
The chemistry and biology of mucin-type O-linked glycosylation
Mucin-type O-linked glycosylation is a fundamental post-translational modification that is
involved in a variety of important biological processes. However, the lack of chemical tools to …
involved in a variety of important biological processes. However, the lack of chemical tools to …
[HTML][HTML] Recent advances in the development of sialyltransferase inhibitors to control cancer metastasis: A comprehensive review
Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …
health and economic burden. One of the mechanisms that enables metastasis is …
Understanding the chemistry and biology of glycosylation with glycan synthesis
Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying …
glycans present in biological molecules and the lack of convenient tools suitable for studying …
Polypeptide GalNAc-Ts: from redundancy to specificity
Mucin-type O-glycosylation is a post-translational modification (PTM) that is predicted to
occur in more than the 80% of the proteins that pass through the Golgi apparatus. This PTM …
occur in more than the 80% of the proteins that pass through the Golgi apparatus. This PTM …
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases
TA Gerken, O Jamison, CL Perrine, JC Collette… - Journal of Biological …, 2011 - ASBMB
Mammalian mucin-type O-glycosylation is initiated by a large family of∼ 20 UDP-GalNAc:
polypeptide α-N-acetylgalactosaminyltransferases (ppGalNAc Ts) that transfer α-GalNAc …
polypeptide α-N-acetylgalactosaminyltransferases (ppGalNAc Ts) that transfer α-GalNAc …