The Ka/Ks ratio: diagnosing the form of sequence evolution

LD Hurst - TRENDS in Genetics, 2002 - cell.com
There are several different ways you could do this. There is an excellent free package for
PCs called MEGA2 that implements loads of different methods: http://www. megasoftware …

The complete sequence of a human genome

S Nurk, S Koren, A Rhie, M Rautiainen, AV Bzikadze… - Science, 2022 - science.org
Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

The origin and evolution of model organisms

SB Hedges - Nature Reviews Genetics, 2002 - nature.com
The phylogeny and timescale of life are becoming better understood as the analysis of
genomic data from model organisms continues to grow. As a result, discoveries are being …

Synonymous mutations in representative yeast genes are mostly strongly non-neutral

X Shen, S Song, C Li, J Zhang - Nature, 2022 - nature.com
Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …

Complete genomic and epigenetic maps of human centromeres

N Altemose, GA Logsdon, AV Bzikadze, P Sidhwani… - Science, 2022 - science.org
Existing human genome assemblies have almost entirely excluded repetitive sequences
within and near centromeres, limiting our understanding of their organization, evolution, and …

MEGA6: molecular evolutionary genetics analysis version 6.0

K Tamura, G Stecher, D Peterson… - … biology and evolution, 2013 - academic.oup.com
We announce the release of an advanced version of the Molecular Evolutionary Genetics
Analysis (MEGA) software, which currently contains facilities for building sequence …

Predicting functional effect of human missense mutations using PolyPhen‐2

I Adzhubei, DM Jordan… - Current protocols in …, 2013 - Wiley Online Library
Abstract PolyPhen‐2 (Polymorphism Phenoty** v2), available as software and via a Web
server, predicts the possible impact of amino acid substitutions on the stability and function …

From telomere to telomere: The transcriptional and epigenetic state of human repeat elements

SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

[HTML][HTML] Antibody evasion of SARS-CoV-2 Omicron BA. 1, BA. 1.1, BA. 2, and BA. 3 sub-lineages

J Ai, X Wang, X He, X Zhao, Y Zhang, Y Jiang, M Li… - Cell host & …, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant has evolved into four sub-lineages—BA. 1, BA.
1.1, BA. 2, and BA. 3—with BA. 2 becoming dominant worldwide. We and others have …

MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods

K Tamura, D Peterson, N Peterson… - Molecular biology …, 2011 - academic.oup.com
Comparative analysis of molecular sequence data is essential for reconstructing the
evolutionary histories of species and inferring the nature and extent of selective forces …