Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

A key challenge of analyzing data from high-resolution spatial profiling technologies is to
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …

Summary Layer 1 (L1) of the neocortex acts as a nexus for the collection and processing of
widespread information. By integrating ascending inputs with extensive top-down activity …

Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes …

Complex neocortical functions rely on networks of diverse excitatory and inhibitory neurons.
While local connectivity rules between major neuronal subclasses have been established …

During cerebral cortex development, excitatory pyramidal neurons (PNs) establish specific
projection patterns while receiving inputs from GABAergic inhibitory interneurons (INs) …

Hippocampal somatostatin-expressing (Sst) GABAergic interneurons (INs) exhibit
considerable anatomical and functional heterogeneity. Recent single-cell transcriptome …

Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in
regulating cognitive, social and valence systems. However, it remains largely unknown at …

Diverse types of inhibitory interneurons (INs) impart computational power and flexibility to
neocortical circuits. Whereas markers for different IN types in cortical layers 2–6 (L2–L6) …