Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitochondrial and lysosomal function are intricately related and critical for maintaining
cellular homeostasis, as highlighted by multiple diseases linked to dysfunction of both …

Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between
both organelles, but their role in normal and diseased human neurons remains unknown. In …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Rationale: Ischemic heart disease remains a primary threat to human health, while its
precise etiopathogenesis is still unclear. TBC domain family member 15 (TBC1D15) is a …

In the last decade, the traditional view of lysosomes has been challenged by the recognition
that lysosomes are not only degradative organelles, but also metabolic sensors that play a …

Lysosomes are degradative organelles and play vital roles in a variety of cellular processes.
Ion channels on the lysosomal membrane are key regulators of lysosomal function …

Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their
vital functions, mitochondrial quality control (MQC) systems are in place to support organelle …

Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient
sensing, and autophagy. Live imaging has revealed lysosome subpopulations with …