In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

Primates and rodents, which descended from a common ancestor around 90 million years
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the
diversity of GABAergic interneurons. This diversity poses general questions for neural circuit …

Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …

Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

One of the hallmarks of the cerebral cortex is the extreme diversity of interneurons,–. The two
largest subtypes of cortical interneurons, parvalbumin-and somatostatin-positive cells, are …

Human pluripotent stem cells are a powerful tool for modeling brain development and
disease. The human cortex is composed of two major neuronal populations: projection …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …