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[HTML][HTML] Bioactive sphingolipids: metabolism and function
Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and …
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and …
The sphingolipid salvage pathway in ceramide metabolism and signaling
Sphingolipids are important components of eukaryotic cells, many of which function as
bioactive signaling molecules. Of these, ceramide is a central metabolite and plays key roles …
bioactive signaling molecules. Of these, ceramide is a central metabolite and plays key roles …
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still
obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although …
obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although …
Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Myonectin is an exercise-induced myokine that protects the heart from ischemia-reperfusion injury
N Otaka, R Shibata, K Ohashi, Y Uemura… - Circulation …, 2018 - ahajournals.org
Rationale: Physical exercise provides benefits for various organ systems, and some of
systemic effects of exercise are mediated through modulation of muscle-derived secreted …
systemic effects of exercise are mediated through modulation of muscle-derived secreted …
Patterning the vertebrate heart
The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …
changing sets of instructions from their environment and from within. These instructions …
Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity
Pediatric obesity is a progressive, chronic disease that can lead to serious cardiometabolic
complications. Here we investigated the peripheral lipidome in 958 children and …
complications. Here we investigated the peripheral lipidome in 958 children and …
Physiological and pathophysiological aspects of ceramide
Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …
in the activity of signaling proteins but also requires a reorganization of the topology of the …
Endometriosis and cardiovascular disease
Endometriosis is a chronic gynaecological disease affecting 1 in 10 reproductive-age
women. It is defined as the presence of endometrium-like tissue outside the uterus. Beyond …
women. It is defined as the presence of endometrium-like tissue outside the uterus. Beyond …
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in
the regulation of cardiovascular and renal physiology containing two distinct domains …
the regulation of cardiovascular and renal physiology containing two distinct domains …