Omics, such as genomics, transcriptome and proteomics, has been affected by the era of big
data. A huge amount of high dimensional and complex structured data has made it no …

Cell-penetrating peptides (CPPs) facilitate the delivery of therapeutically relevant molecules,
including DNA, proteins and oligonucleotides, into cells both in vitro and in vivo. This unique …

N 6-Methyladenosine (m6A) refers to methylation modification of the adenosine nucleotide
acid at the nitrogen-6 position. Many conventional computational methods for identifying N 6 …

Background: Detecting DNA-binding proteins (DBPs) based on biological and chemical
methods is time-consuming and expensive. Objective: In recent years, the rise of …

The release of interleukin (IL)-6 is stimulated by antigenic peptides from pathogens as well
as by immune cells for activating aggressive inflammation. IL-6 inducing peptides are …

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder that seriously
affects communication and sociality of patients. It is crucial to accurately identify patients with …

Anticancer peptides constitute one of the most promising therapeutic agents for combating
common human cancers. Using wet experiments to verify whether a peptide displays …

Key message We proposed an ensemble convolutional neural network model to identify
sgRNA high on-target activity in four crops and we used one-hot encoding and k-mers for …

The promoter region is located near the transcription start sites and regulates transcription
initiation of the gene by controlling the binding of RNA polymerase. Thus, promoter region …

Background: Thermophilic proteins can maintain good activity under high temperature,
therefore, it is important to study thermophilic proteins for the thermal stability of proteins …