Computer-aided drug design (CADD) is an emerging field that has drawn a lot of interest
because of its potential to expedite and lower the cost of the drug development process …

Over the past ten years, the number of three-dimensional protein structures identified by
advanced science and technology increases, and the gene information becomes more …

Abstract Cyclooxygenase‐2 (COX‐2) is a key aspect of the physiology and pathogenesis of
various cancer types. Overexpression of this enzyme is responsible for the elevated …

Aromatase enzyme plays a fundamental role in the development of estrogen receptors, and
due to this functionality, the enzyme has gained significant attention as a therapeutic for …

Human EGFR (epidermal growth factor receptor) family of tyrosine kinase receptors consists
of four members, ErbB1-4. Abnormalities in the ErbB family characterize a variety of human …

Massively parallel sequencing, genomic and proteomic technologies have provided near
complete resolution of signaling landscape of breast cancer (BCa). NEDD4 family of E3 …

Targeting ErbB family of receptors is an important therapeutic option, because of its
essential role in the broad spectrum of human cancers, including non-small cell lung cancer …

IRS1 is a cytoplasmic adaptor protein that helps in cellular growth, glucose metabolism,
proliferation, and differentiation. Highly disordered (insulin receptor substrate 1) IRS1 …

Background: Breast cancer ranks first in women and is the second most common type of
cancer overall. It is the most important barrier to the rise of life expectancy, globally affecting …

Target-based drug discovery tools have been used with success in the pharmaceutical
industry. They have become the fundamental methodologies for discovering new drugs in …