Animal models of depression: what can they teach us about the human disease?

M Becker, A Pinhasov, A Ornoy - Diagnostics, 2021 - mdpi.com
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Sex differences in antidepressant efficacy

TA LeGates, MD Kvarta, SM Thompson - Neuropsychopharmacology, 2019 - nature.com
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …

[HTML][HTML] The cafeteria diet: A standardized protocol and its effects on behavior

JF Lalanza, EMS Snoeren - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Obesity is a major health risk, with junk food consumption playing a central role in weight
gain, because of its high palatability and high-energy nutrients. The Cafeteria (CAF) diet …

[HTML][HTML] Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents

Q Li, Y Takeuchi, J Wang, L Gellért, L Barcsai… - Neuron, 2023 - cell.com
Although the etiology of major depressive disorder remains poorly understood, reduced
gamma oscillations is an emerging biomarker. Olfactory bulbectomy, an established model …

Potential role of curcumin for the treatment of major depressive disorder

AL Lopresti - CNS drugs, 2022 - Springer
Curcumin is the major biologically active polyphenolic constituent in the turmeric plant
(Curcuma longa) that has been shown to have antioxidant, anti-inflammatory …

Animal models of depression: pros and cons

J Harro - Cell and tissue research, 2019 - Springer
Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

Mechanisms linking olfactory impairment and risk of mortality

V Van Regemorter, T Hummel, F Rosenzweig… - Frontiers in …, 2020 - frontiersin.org
Olfaction is a sense involved in a complex set of tasks, influencing eating behavior,
increasing awareness of environmental hazards and affecting social communication …

[HTML][HTML] Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience

MC Flux, CA Lowry - Neurobiology of disease, 2020 - Elsevier
Depression affects at least 322 million people globally, or approximately 4.4% of the world's
population. While the earnestness of researchers and clinicians to understand and treat …

Neuromodulation and hippocampal neurogenesis in depression: a sco** review

AD Flores, WS Yu, ML Fung, LW Lim - Brain Research Bulletin, 2022 - Elsevier
The 'neurogenesis hypothesis of depression'emphasizes the importance of upregulated
hippocampal neurogenesis for the efficacy of antidepressant treatment. Neuromodulation is …

Intranasal delivery of icariin via a nanogel-thermoresponsive hydrogel compound system to improve its antidepressant-like activity

D Xu, YR Lu, N Kou, MJ Hu, QS Wang… - International Journal of …, 2020 - Elsevier
Although icariin has been reported to have antidepressant-like effects in different animal
models, its poor oral bioavailability and low efficiency of delivery to the brain limit its …