Recombinant pseudorabies virus usage in vaccine development against swine infectious disease

M Zhou, M Abid, S Cao, S Zhu - Viruses, 2023 - mdpi.com
Pseudorabies virus (PRV) is the pathogen of pseudorabies (PR), which belongs to the alpha
herpesvirus subfamily with a double stranded DNA genome encoding approximately 70 …

Genome editing strategies to protect livestock from viral infections

JH Söllner, TC Mettenleiter, B Petersen - Viruses, 2021 - mdpi.com
The livestock industry is constantly threatened by viral disease outbreaks, including
infections with zoonotic potential. While preventive vaccination is frequently applied, disease …

Genome editing of pseudorabies virus in the CRISPR/Cas9 era: a mini-review

HM Wang, YY Qiao, BY Cai, J Tan, L Na… - Frontiers in Veterinary …, 2023 - frontiersin.org
Pseudorabies virus (PRV) is an important swine virus that has a significant impact on the
global swine industry. PRV is a member of the herpesvirus family, specifically the …

Optimizing encephalomyocarditis virus VP1 protein assembly on pseudorabies virus envelope via US9 protein anchoring

BR Ren, H Qin, YF Zhang, XY Du, HC Sun, Y Luo… - Virulence, 2025 - Taylor & Francis
Live herpesvirus-vectored vaccines are critical in veterinary medicine, but they can
sometimes offer insufficient protection due to suboptimal antigen expression or localization …

[HTML][HTML] Immunization of mice with delayed lysis Salmonella expressing PCV2b cap protein enhanced mucosal and innate immunity and reduced viral load

G Zhang, Y Shen, Z Wang, G Hao, F Wang - Veterinary Vaccine, 2024 - Elsevier
Abstract Porcine circovirus type 2 (PCV2) has been recognized as a critical pathogen
associated with numerous porcine circovirus-related diseases. Immunization is commonly …

A rapid and versatile reverse genetic approach and visualization animal models for emerging zoonotic pseudorabies virus

Y Zhang, X Li, J Zhang, Y Duan, P Chen, L Shi… - Antiviral Research, 2024 - Elsevier
Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily and a causative
pathogen of Aujeszky's disease, has a broad host range including domestic and wild …

Characterization of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the Cap protein of porcine circovirus type 2d

RQ Xu, LQ Wang, HH Zheng, RB Tian, LL Zheng… - … and Infectious Diseases, 2023 - Elsevier
Abstract Porcine circovirus type 2 (PCV2) plays a key role in the etiology of PCV2-
associated disease (PCVAD), and its predominant strain is PCV2d which is not completely …

Live attenuated Salmonella enterica serovar Choleraesuis vector delivering a virus-like particles induces a protective immune response against porcine circovirus …

Y Li, Y Sun, Y Zhang, S Wang, H Shi - Vaccine, 2022 - Elsevier
The virus-like particles (VLPs) of porcine circovirus type 2 (PCV2) is an attractive vaccine
candidate that retains the natural conformation of the virion but lacks the viral genome to …

Characterization of B cell receptor H-CDR3 repertoire of spleen in PRV-infected mice

L Deng, F Yang, Z Xu, F Li, J Zhao, H Deng… - BMC Veterinary …, 2022 - Springer
Pseudorabies virus (PRV), also known as suid Alphaherpesvirus 1 (SuHV-1), which is one
of the most devastating infectious pathogen of swine industry worldwide. Vaccination is the …

Using the CRISPR-Cas System to Solve Porcine Viral Infection–related Issues

F Liao, YD Tang, L Tan, J Yao, C Zheng… - The CRISPR …, 2021 - liebertpub.com
Viral infection–associated diseases seriously affect the development of the swine industry
and pose a potential threat to the health of humans. Fortunately, the emergence of CRISPR …