Depression is the principal cause of illness and disability in the world. Studies charting the
prevalence of depression among children and adolescents report high percentages of …

Recent scientific and technological advances have brought us closer to being able to apply
a true biopsychosocial approach to the study of resilience in humans. Decades of research …

Susceptibility and resilience to stress depend on 1) the timing of the exposure with respect to
development, 2) the time across the life span at which effects are measured, and 3) the …

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Despite the significant prevalence of Major Depressive Disorder in the pediatric population,
the pathophysiology of this condition remains unclear, and the treatment outcomes poor …

Childhood abuse (CA) is a prevalent global health concern, increasing the risk of negative
mental health outcomes later in life. In the literature, CA is commonly defined as physical …

Both history of early-life stress (ELS) and female sex are associated with increased risk for
depression. The complexity of how ELS interacts with brain development and sex to impart …

Background Child abuse and other forms of adversity are associated with alterations in
threat processing and emotion regulation brain circuits. Objective The goal of the current …

The extracellular space is occupied by a complex network of proteins creating a mesh-like
assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like …