Spermatogenesis: the commitment to meiosis

MD Griswold - Physiological reviews, 2016 - journals.physiology.org
Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

[HTML][HTML] Spermatogonial stem cells and spermatogenesis in mice, monkeys and men

AP Fayomi, KE Orwig - Stem cell research, 2018 - Elsevier
Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq

CD Green, Q Ma, GL Manske, AN Shami, X Zheng… - Developmental cell, 2018 - cell.com
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis

Z Lin, PJ Hsu, X ** and X chromosome transcriptional dynamics during mouse spermatogenesis
C Ernst, N Eling, CP Martinez-Jimenez… - Nature …, 2019 - nature.com
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

The germ cell fate of cynomolgus monkeys is specified in the nascent amnion

K Sasaki, T Nakamura, I Okamoto, Y Yabuta… - Developmental cell, 2016 - cell.com
The germ cell lineage ensures reproduction and heredity. The mechanism for germ cell
specification in primates, including humans, has remained unknown. In primates, upon …

Retinoic acid receptors: from molecular mechanisms to cancer therapy

A Di Masi, L Leboffe, E De Marinis, F Pagano… - Molecular aspects of …, 2015 - Elsevier
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Spermatogonial stem cells

H Kubota, RL Brinster - Biology of reproduction, 2018 - academic.oup.com
Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …