Veterinary drugs in the environment and their toxicity to plants

H Bártíková, R Podlipná, L Skálová - Chemosphere, 2016 - Elsevier
Veterinary drugs used for treatment and prevention of diseases in animals represent
important source of environmental pollution due to intensive agri-and aquaculture …

Natural products are a promising source for anthelmintic drug discovery

KLTD Jayawardene, EA Palombo, PR Boag - Biomolecules, 2021 - mdpi.com
Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of
the major causative factors for physical and intellectual growth retardation in the develo** …

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

B Onken, M Driscoll - PloS one, 2010 - journals.plos.org
Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to
extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms …

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

J Fang, J Yang, X Wu, G Zhang, T Li, X Wang… - Aging cell, 2018 - Wiley Online Library
Metformin, an FDA‐approved antidiabetic drug, has been shown to elongate lifespan in
animal models. Nevertheless, the effects of metformin on human cells remain unclear. Here …

A living model for obesity and aging research: Caenorhabditis elegans

P Shen, Y Yue, Y Park - Critical reviews in food science and …, 2018 - Taylor & Francis
Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans

JN Stirman, MM Crane, SJ Husson, S Wabnig… - Nature …, 2011 - nature.com
The ability to optically excite or silence specific cells using optogenetics has become a
powerful tool to interrogate the nervous system. Optogenetic experiments in small organisms …

Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment

OA Idris, OA Wintola, AJ Afolayan - Heliyon, 2019 - cell.com
The morbidity caused by parasite worms on susceptible hosts is of great concern and
studies were carried out to explain the mechanism of infection, prevalence, host-parasite …

[HTML][HTML] Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones

J Kearn, E Ludlow, J Dillon, V O'Connor… - Pesticide Biochemistry …, 2014 - Elsevier
Plant parasitic nematodes infest crops and present a threat to food security worldwide.
Currently available chemical controls eg methyl bromide, organophosphates and …

Evaluation of anthelmintic and anti-inflammatory activity of 1, 2, 4-triazole derivatives

R Paprocka, P Kołodziej, M Wiese-Szadkowska… - Molecules, 2022 - mdpi.com
Parasitic diseases, caused by intestinal helminths, remain a very serious problem in both
human and veterinary medicine. While searching for new nematicides we examined a series …

[HTML][HTML] Synthesis and anthelmintic activity of novel thiosemicarbazide and 1, 2, 4-triazole derivatives: in vitro, in vivo, and in silico study

P Kołodziej, M Wujec, M Doligalska… - Journal of Advanced …, 2024 - Elsevier
Introduction Intestinal parasitic infections are neglected diseases and, due to the increasing
resistance of parasites to available drugs, they pose an increasing therapeutic challenge …