The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-
quality and freely accessible set of protein sequences annotated with functional information …

Multiple sequence alignment (MSA) is an essential cornerstone in bioinformatics, which can
reveal the potential information in biological sequences, such as function, evolution and …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

The development of spatial transcriptome sequencing technology has revolutionized our
comprehension of complex tissues and propelled life and health sciences into an era of …

Understanding the intricate relationships between gene expression levels and epigenetic
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …

Abstract The Rat Genome Database (RGD, https://rgd. mcw. edu) has evolved from simply a
resource for rat genetic markers, maps, and genes, by adding multiple genomic data types …

Biomedical data is accumulating at a fast pace and integrating it into a unified framework is a
major challenge, so that multiple views of a given biological event can be considered …

Gut microbiota plays a significant role in maintaining host health, and conversely, disorders
potentially lead to dysbiosis, an imbalance in the composition of the gut microbial …

The high cost of large-scale, high-coverage whole-genome sequencing has limited its
application in genomics and genetics research. The common approach has been to impute …

The “RNA world” represents a novel frontier for the study of fundamental biological
processes and human diseases and is paving the way for the development of new drugs …