Chemotherapy: a double-edged sword in cancer treatment

N Behranvand, F Nasri, R Zolfaghari Emameh… - Cancer immunology …, 2022 - Springer
Chemotherapy is a well-known and effective treatment for different cancers; unfortunately, it
has not been as efficient in the eradication of all cancer cells as been expected. The …

Immunotherapeutic approaches for small-cell lung cancer

WT Iams, J Porter, L Horn - Nature Reviews Clinical Oncology, 2020 - nature.com
Immune-checkpoint inhibitors (ICIs) are approved in the first-line and third-line settings for
patients with extensive-stage or relapsed small-cell lung cancer (SCLC), respectively. In the …

[HTML][HTML] Sintilimab plus platinum and gemcitabine as first-line treatment for advanced or metastatic squamous NSCLC: results from a randomized, double-blind, phase …

C Zhou, L Wu, Y Fan, Z Wang, L Liu, G Chen… - Journal of Thoracic …, 2021 - Elsevier
Introduction The standard chemotherapy for squamous NSCLC (sqNSCLC) includes
platinum plus gemcitabine. Sintilimab, an anti–programmed cell death protein 1 antibody …

Radiotherapy combination opportunities leveraging immunity for the next oncology practice

FG Herrera, J Bourhis, G Coukos - CA: a cancer journal for …, 2017 - Wiley Online Library
Approximately one‐half of patients with newly diagnosed cancer and many patients with
persistent or recurrent tumors receive radiotherapy (RT), with the explicit goal of eliminating …

Nivolumab in combination with platinum‐based doublet chemotherapy for first-line treatment of advanced non–small-cell lung cancer

NA Rizvi, MD Hellmann, JR Brahmer… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Nivolumab, a fully human immunoglobulin G4 programmed death-1 immune
checkpoint inhibitor antibody, has demonstrated improved survival in previously treated …

Development of peptide‐based vaccines for cancer

N Abd-Aziz, CL Poh - Journal of Oncology, 2022 - Wiley Online Library
Peptides cancer vaccines are designed based on the epitope peptides that can elicit
humoral and cellular immune responses targeting tumor‐associated antigens (TAAs) or …

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

L Bracci, G Schiavoni, A Sistigu… - Cell Death & …, 2014 - nature.com
Conventional anticancer chemotherapy has been historically thought to act through direct
killing of tumor cells. This concept stems from the fact that cytotoxic drugs interfere with DNA …

Tumor-homing and immune-reprogramming cellular nanovesicles for photoacoustic imaging-guided phototriggered precise chemoimmunotherapy

Z Fan, Y Wang, L Li, F Zeng, Q Shang, Y Liao… - ACS …, 2022 - ACS Publications
Many studies have focused on develo** effective therapeutic strategies to selectively
destroy primary tumors, eliminate metastatic lesions, and prevent tumor recurrence with …

[HTML][HTML] A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance

J Zhou, N Lyu, Q Wang, M Yang, ET Kimchi, K Cheng… - Cancer letters, 2023 - Elsevier
Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

DG You, VG Deepagan, W Um, S Jeon, S Son… - Scientific reports, 2016 - nature.com
The non-invasive photodynamic therapy has been limited to treat superficial tumours,
primarily ascribed to poor tissue penetration of light as the energy source. Herein, we …