Targeted modulation of immune cells and tissues using engineered biomaterials
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …
Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer
Although systemic immunotherapy has achieved durable responses and improved survival
for certain patients and cancer types, low response rates and immune system-related …
for certain patients and cancer types, low response rates and immune system-related …
Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy
Nanorobotic manipulation to access subcellular organelles remains unmet due to the
challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as …
challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as …
Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy
Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies,
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …
A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics
N Niu, Y Yu, Z Zhang, M Kang, L Wang, Z Zhao… - Chemical …, 2022 - pubs.rsc.org
The exploration of cellular organelle-specific anchoring photosensitizers with both
prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) …
prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) …
Image-guided intratumoral immunotherapy: Develo** a clinically practical technology
Immunotherapy has revolutionized the contemporary oncology landscape, with durable
responses possible across a range of cancer types. However, the majority of cancer patients …
responses possible across a range of cancer types. However, the majority of cancer patients …
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies
Effective antitumor immunity in mice requires activation of the type I interferon (IFN)
response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer …
response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer …
Biomaterials-mediated engineering of the immune system
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …
diseases, and is fundamental to the development of vaccines. However, optimally safe and …
Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors
Recent advancements in photoacoustic (PA) imaging have leveraged reversibly
photoswitchable chromophores, known for their dual absorbance states, to enhance …
photoswitchable chromophores, known for their dual absorbance states, to enhance …
TLR Agonists Delivered by Plant Virus and Bacteriophage Nanoparticles for Cancer Immunotherapy
E Jung, YH Chung, NF Steinmetz - Bioconjugate Chemistry, 2023 - ACS Publications
Toll-like receptors (TLRs) are promising targets in cancer immunotherapy due to their role in
activating the immune system; therefore, various small-molecule TLR agonists have been …
activating the immune system; therefore, various small-molecule TLR agonists have been …