Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety
of physiological processes, including development of multiple diseases. In particular …

Cancer stem cells exhibit self-renewal, tumorigenesis, and a high differentiation potential.
These cells have been detected in every type of cancer, and different signaling pathways …

Circulating testosterone is easily aromatized to estradiol and reduced to dihydrotestosterone
in target tissues and elsewhere in the body. Thus, the actions of testosterone can be …

The androgen receptor (AR) is expressed in many cell types, and its related signaling is
widely investigated in hormone-dependent cancers such as prostate and breast. The …

Patients with castration-resistant prostate cancer (CRPC) are generally unresponsive to
tumor targeted and immunotherapies. Whether genetic alterations acquired during the …