Microglia: agents of the CNS pro-inflammatory response
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
Alternatively activated microglia and macrophages in the central nervous system
R Franco, D Fernández-Suárez - Progress in neurobiology, 2015 - Elsevier
Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …
infections. From a resting state they may undertake two activation pathways, the classical …
The immunology of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
An Overview of in vitro Methods to Study Microglia
R Timmerman, SM Burm, JJ Bajramovic - Frontiers in cellular …, 2018 - frontiersin.org
Neuroinflammation is a common feature in neurodegenerative diseases and strategies to
modulate neuroinflammatory processes are increasingly considered as therapeutic options …
modulate neuroinflammatory processes are increasingly considered as therapeutic options …
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
Parkinson's disease is characterized by accumulation of α-synuclein (αSyn). Release of
oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via …
oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via …
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Inflammatory response induced by microglia plays a critical role in the demise of neuronal
populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in …
populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in …
Microglia response during Parkinson's disease: alpha-synuclein intervention
The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …
disease and other Lewy body brain disorders has had a great relevance in the …
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
WP Flavin, L Bousset, ZC Green, Y Chu… - Acta …, 2017 - Springer
Numerous pathological amyloid proteins spread from cell to cell during neurodegenerative
disease, facilitating the propagation of cellular pathology and disease progression …
disease, facilitating the propagation of cellular pathology and disease progression …
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed
different phenotypes that are inherently associated with disease conditions. A common …
different phenotypes that are inherently associated with disease conditions. A common …