Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage
and regulated release of calcium and as the entrance to the secretory pathway. Protein …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Solid tumors typically develop hostile microenvironments characterized by irregular
vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is observed in many human diseases, including cancers. Cellular adaptation to ER stress is …

Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has
been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in …

Over the past few decades, understandings and evidences concerning the role of
endoplasmic reticulum (ER) stress in deciding the cell fate have been constantly growing …