Trypanothione reductase and superoxide dismutase as current drug targets for Trypanosoma cruzi: an overview of compounds with activity against Chagas disease
I Beltran-Hortelano, S Perez-Silanes… - Current Medicinal …, 2017 - ingentaconnect.com
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …
Synthesis, structural, and intriguing electronic properties of symmetrical bis-aryl-α, β-unsaturated ketone derivatives
Three symmetrical bis-aryl-α, β-unsaturated ketone derivatives, 2, 6-di ((E)-benzylidene)-
cyclohexan-1-one (DBC), 2, 6-bis ((E)-4-chlorobenzylidene) cyclohexan-1-one (BCC), and …
cyclohexan-1-one (DBC), 2, 6-bis ((E)-4-chlorobenzylidene) cyclohexan-1-one (BCC), and …
Acid catalyzed one-pot approach towards the synthesis of curcuminoid systems: unsymmetrical diarylidene cycloalkanones, exploration of their single crystals, optical …
In the present study crystalline unsymmetrical diarylidene ketone derivatives BNTP and
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review
Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …
Facile preparation, characterization, SC-XRD and DFT/DTDFT study of diversely functionalized unsymmetrical bis-aryl-α, β-unsaturated ketone derivatives
The current research work is about the synthesis of diversely functionalized unsymmetrical
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
Dibenzylideneacetone induces apoptosis in cervical cancer cells through Ros-mediated mitochondrial damage
AP Zani, CP Zani, ZU Din, E Rodrigues-Filho… - Antioxidants, 2023 - mdpi.com
Cervical cancer is a health problem among women worldwide. Considering the limitations of
prevention and antineoplastic chemotherapy against cervical cancer, research is needed to …
prevention and antineoplastic chemotherapy against cervical cancer, research is needed to …
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei
Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …
Exploration of structural, electronic and third order nonlinear optical properties of crystalline chalcone systems: Monoarylidene and unsymmetrical diarylidene …
In the current study monoarylidene and unsymmetrical diarylidene cycloalkanes, MBMHP,
MABP, MBHP, and MBCP have been prepared. Their molecular structures were confirmed …
MABP, MBHP, and MBCP have been prepared. Their molecular structures were confirmed …
Dibenzylideneacetones are potent trypanocidal compounds that affect the Trypanosoma cruzi redox system
D Lazarin-Bidóia, VC Desoti, SC Martins… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …
especially in the chronic phase of the disease. Our previous study reported the strong …
Molecular design of curcumin analogues with potent antioxidant properties and thermodynamic evaluation of their mechanism of free radical scavenge
Background Free radical attack of cellular structures in the human system is the major cause
of various forms of degenerative diseases. Consequently, recent research has been focused …
of various forms of degenerative diseases. Consequently, recent research has been focused …