Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

On the basis of many literature measurements, a critical overview is given on essential
noncovalent interactions in synthetic supramolecular complexes, accompanied by analyses …

This review offers an introduction to the principles and generic applications of FT‐ICR mass
spectrometry, directed to readers with no prior experience with the technique. We are able to …

Electrospray ionization mass spectrometry has been used to study protein interactions
driven by noncovalent forces. The gentleness of the electrospray ionization process allows …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

The generation and/or optimization of lead compounds by combinatorial methods has
become widely accepted in medicinal chemistry, and is the subject of continued …

During the last six years, combinatorial chemistry has attracted enormous attention from the
pharmaceutical industry because it can greatly facilitate the drug discovery process. 1 At the …

The X-ray crystal structure of the adduct between the zinc metalloenzyme carbonic
anhydrase II (CA, EC 4.2. 1.1) with the recently discovered natural product coumarin …

This paper describes the immobilization of ten proteins and two low-molecular-weight
ligands on mixed selfassembled monolayers (SAMs) of alkanethiolates on gold generated …

Electrospray ionization mass spectrometry (ESI-MS) has demonstrated utility for the
detection and study of weakly bound, noncovalent complexes, including protein interactions …