Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
Cellular senescence and senolytics: the path to the clinic
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …
disorders and diseases. One such process is cellular senescence, which entails a state of …
An aged immune system drives senescence and ageing of solid organs
Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …
mortality of the elderly,. To define the contribution of immune system ageing to organism …
[HTML][HTML] Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 …
Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …
Senolytic drugs: from discovery to translation
Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Measuring biological aging in humans: A quest
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
Immunosenescence: a key player in cancer development
J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study
Background Globally, there is a paucity of multimorbidity and comorbidity data, especially for
minority ethnic groups and younger people. We estimated the frequency of common disease …
minority ethnic groups and younger people. We estimated the frequency of common disease …
The role of cellular senescence in ageing and endocrine disease
With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …