Evolving challenges in hepatic fibrosis
SL Friedman - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …
Fermentation, a feasible strategy for enhancing bioactivity of herbal medicines
Herbal drugs, which possess immunomodulatory, anti-inflammatory, anti-diabetic, anti-
infective, and anti-allergic activities, encompass various therapeutic areas, and have been …
infective, and anti-allergic activities, encompass various therapeutic areas, and have been …
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …
[HTML][HTML] Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …
Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis
Background & Aims Interactions between CC chemokine receptor types 2 (CCR2) and 5
(CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting …
(CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting …
[PDF][PDF] Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: the Rotterdam study
EM Koehler, EPC Plompen, JNL Schouten… - …, 2016 - Wiley Online Library
Given that little is known about the prevalence of, and factors associated with, liver fibrosis in
the general population, we aimed to investigate this in a large, well‐characterized cohort by …
the general population, we aimed to investigate this in a large, well‐characterized cohort by …
[PDF][PDF] Sarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: nationwide surveys …
Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study
investigated whether sarcopenia is associated with significant liver fibrosis in subjects with …
investigated whether sarcopenia is associated with significant liver fibrosis in subjects with …
[PDF][PDF] Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States
The clinical and public health significance of nonalcoholic fatty liver disease (NAFLD) is not
well established. We investigated the long‐term effect of NAFLD on mortality. This analysis …
well established. We investigated the long‐term effect of NAFLD on mortality. This analysis …
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2
AJ O'brien, JN Fullerton, KA Massey, G Auld… - Nature medicine, 2014 - nature.com
Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display
an increased predisposition to and mortality from infection due to multimodal defects in the …
an increased predisposition to and mortality from infection due to multimodal defects in the …
LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis
M Xu, HH Xu, Y Lin, X Sun, LJ Wang, ZP Fang, XH Su… - Cell, 2019 - cell.com
Liver fibrosis is a very common condition seen in millions of patients with various liver
diseases, and yet no effective treatments are available owing to poorly characterized …
diseases, and yet no effective treatments are available owing to poorly characterized …