Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as
phytic acid or IP6, with their biological activities received much attention for their role in …

Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …

Abstract Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …

The transcriptional corepressor complex CoREST is one of seven histone deacetylase
complexes that regulate the genome through controlling chromatin acetylation. The CoREST …

Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …