The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
Anticancer therapy with HDAC inhibitors: mechanism-based combination strategies and future perspectives
R Jenke, N Reßing, FK Hansen, A Aigner, T Büch - Cancers, 2021 - mdpi.com
Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S
H Guan, P Wang, P Zhang, C Ruan, Y Ou, B Peng… - Nature, 2023 - nature.com
Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in
gene regulation,,–. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation …
gene regulation,,–. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation …
Role of inositols and inositol phosphates in energy metabolism
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as
phytic acid or IP6, with their biological activities received much attention for their role in …
phytic acid or IP6, with their biological activities received much attention for their role in …
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription
W Wei, X Liu, J Chen, S Gao, L Lu, H Zhang, G Ding… - Cell research, 2017 - nature.com
Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …
HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
J Li, L Lu, L Liu, X Ren, J Chen, X Yin, Y **ao, J Li… - Cell Discovery, 2023 - nature.com
Lysine succinylation is one of the major post-translational modifications occurring on
histones and is believed to have significant roles in regulating chromatin structure and …
histones and is believed to have significant roles in regulating chromatin structure and …
[HTML][HTML] Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
PJ Watson, CJ Millard, AM Riley, NS Robertson… - Nature …, 2016 - nature.com
Abstract Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …