[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies

S Adhikari, P Nath, A Das, A Datta, N Baildya… - Biomedicine & …, 2024 - Elsevier
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway

H Zhou, D Tang, Y Yu, L Zhang, B Wang… - Nature …, 2023 - nature.com
Tumor metastases are considered the leading cause of cancer-associated deaths. While
clinically applied drugs have demonstrated to efficiently remove the primary tumor …

A nanoencapsulated Ir (III)-phthalocyanine conjugate as a promising photodynamic therapy anticancer agent

J Bonelli, E Ortega-Forte, G Vigueras… - … applied materials & …, 2024 - ACS Publications
Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development
of efficient and photostable photosensitizing molecules that operate at long wavelengths of …

Potent anticancer activity of a novel iridium metallodrug via oncosis

E Ortega-Forte, S Hernández-García… - Cellular and Molecular …, 2022 - Springer
Oncosis (from Greek ónkos, meaning “swelling”) is a non-apoptotic cell death process
related to energy depletion. In contrast to apoptosis, which is the main form of cell death …

Improving photodynamic therapy anticancer activity of a mitochondria-targeted coumarin photosensitizer using a polyurethane–polyurea hybrid nanocarrier

J Bonelli, E Ortega-Forte, A Rovira, M Bosch… - …, 2022 - ACS Publications
Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential
for overcoming some of the “Achiles' heels” of photodynamic therapy (PDT). Herein, we have …

Mitochondria-targeted iridium (III) complexes encapsulated in liposome induce cell death through ferroptosis and gasdermin-mediated pyroptosis

C Huang, Y Yuan, G Li, S Tian, H Hu, J Chen… - European Journal of …, 2024 - Elsevier
This paper unveils a novel perspective on synthesis and characterization of the ligand 5-
bromo-2-amino-2'-(phenyl-1H-imidazo [4, 5-f][1, 10] phenanthroline)(BAPIP), and its iridium …

Towards Selective Delivery of a Ruthenium (II) Polypyridyl Complex‐Containing Bombesin Conjugate into Cancer Cells

MJSA Silva, R Vinck, Y Wang, B Saubaméa… - …, 2023 - Wiley Online Library
An increasing number of novel Ru (II) polypyridyl complexes have been successfully applied
as photosensitizers (PSs) for photodynamic therapy (PDT). Despite recent advances in …

Targeted liposomes encapsulated iridium (III) compound greatly enhance anticancer efficacy and induce cell death via ferroptosis on HepG2 cells

J Chen, W Li, G Li, X Liu, C Huang, H Nie… - European Journal of …, 2024 - Elsevier
In this study, ligands 2-phenyl-1H-imidazo [4, 5-f][1, 10] phenanthroline (PIP), 2-(2-
nitrophenyl)-1H-imidazo [4, 5-f][1, 10] phenanthroline (NPIP), 2-(2-nitronaphthalen-1-yl)-1H …

[HTML][HTML] Insights into molecular mechanisms of metallodrugs using metallomic studies

S La Manna, D Marasco - Inorganica Chimica Acta, 2024 - Elsevier
Metal ions are the center of an important class of therapeutics, ie metallodrugs for their
unique coordination geometries and redox states. Many cellular functions depend on the …

Systematic study on interfacial polymerization mechanism of toluene diisocyanate and water for the preparation of polyurea microspheres

MS Bashir, XZ Kong, N Ramzan, M Arif, H Bashir… - Inorganic Chemistry …, 2022 - Elsevier
Polyureas (PU) are important materials in wide range of applications from protective
coatings and catalyst supports to biomaterials for drug release and hydrogels. However, it …