Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Increasing evidence suggests that ion channels and pumps not only regulate membrane
potential, ion homeostasis, and electric signaling in excitable cells but also play important …

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets
(the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling …

Brain gliomas are highly epileptogenic. Excitatory glutamatergic mechanisms are involved in
the generation of epileptic activities in the neocortex surrounding gliomas. However …

Epilepsy often develops in patients with glioma, and the two conditions share common
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Glioblastoma, or glioblastoma multiforme (GBM), is described as one of the most invasive
cancer types. Although GBM is a rare disease, with a global incidence of< 10 per 100,000 …