Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to
proliferate in early postnatal life. Here, we propose a model in which a negative feedback …

Background The inference of biological networks from high-throughput data has received
huge attention during the last decade and can be considered an important problem class in …

Abstract Systems Biology may be assimilated to a symbiotic cyclic interplaying between the
forward and inverse problems. Computational models need to be continuously refined …

Drosophila “gap” genes provide the first response to maternal gradients in the early fly
embryo. Gap genes are expressed in a series of broad bands across the embryo during first …

We modelled and calibrated the distributions of the seven-stripe patterns of Even-skipped
(Eve) and Fushi-tarazu (Ftz) pair-rule proteins along the anteroposterior axis of the …

To model the regulation of gene expression in eukaryotes by transcriptional activators and
repressors, we introduce delays in conjugation with the mass action law. Delays are …

From a mass action law approach, we modelled and calibrated the distributions of the seven-
stripe patterns of Even-skipped (\textit {Eve}) and Fushi-tarazu (\textit {Ftz}) proteins in the …

The multicellular incoherent feedforward loop (mIFFL) is an extension of the traditional
intracellular IFFL gene motif where the interacting nodes no longer need to be genes inside …

Living cells can be observed as complex dynamical systems that are constantly remodelling
themselves as response to changes in their environment (Zak et al., 2005). The cell …

We fit the parameters of a differential equations model describing the production of gap-
gene proteins Hunchback and Knirps along the antero-posterior axis of the embryo of …