[HTML][HTML] Hypoxia and brain aging: Neurodegeneration or neuroprotection?
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
Cerebral microvascular pathology in ageing and neurodegeneration
WR Brown and CR Thore (2011) Neuropathology and Applied Neurobiology37, 56–74
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …
Generation of human vascularized brain organoids
MT Pham, KM Pollock, MD Rose, WA Cary… - …, 2018 - journals.lww.com
The aim of this study was to vascularize brain organoids with a patient's own endothelial
cells (ECs). Induced pluripotent stem cells (iPSCs) of one UC Davis patient were grown into …
cells (ECs). Induced pluripotent stem cells (iPSCs) of one UC Davis patient were grown into …
Impact of high altitude on cardiovascular health: current perspectives
Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …
Cognitive deficits in obstructive sleep apnea: insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation
Obstructive sleep apnea (OSA) is a nocturnal breathing disorder that is associated with
cognitive impairment. The primary determinants of cognitive deficits in OSA are thought to be …
cognitive impairment. The primary determinants of cognitive deficits in OSA are thought to be …
Gestational hypoxia and developmental plasticity
Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
Mild hypoxia triggers transient blood–brain barrier disruption: a fundamental protective role for microglia
SK Halder, R Milner - Acta Neuropathologica Communications, 2020 - Springer
We recently demonstrated that when mice are exposed to chronic mild hypoxia (CMH, 8% O
2), blood vessels in the spinal cord show transient vascular leak that is associated with …
2), blood vessels in the spinal cord show transient vascular leak that is associated with …
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Z Wu, H Guo, N Chow, J Sallstrom, RD Bell, R Deane… - Nature medicine, 2005 - nature.com
Neurovascular dysfunction substantially contributes to Alzheimer disease. Here, we show
that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of …
that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of …
The pathobiology of neurovascular aging
As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …
dementia have become leading causes of death and disability. The aging of the …
Cerebral hypoxia: its role in age-related chronic and acute cognitive dysfunction
Postoperative cognitive dysfunction (POCD) has been reported with widely varying
frequency but appears to be strongly associated with aging. Outside of the surgical arena …
frequency but appears to be strongly associated with aging. Outside of the surgical arena …