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Atropisomerism in the pharmaceutically relevant realm
M Basilaia, MH Chen, J Secka… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Atropisomerism is a conformational chirality that occurs when there is hindered
rotation about a σ-bond. While atropisomerism is exemplified by biaryls, it is observed in …
rotation about a σ-bond. While atropisomerism is exemplified by biaryls, it is observed in …
Receptor tyrosine kinase inhibitors in cancer
N Ebrahimi, E Fardi, H Ghaderi, S Palizdar… - Cellular and Molecular …, 2023 - Springer
Targeted therapy is a new cancer treatment approach, involving drugs that particularly target
specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are …
specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are …
Pharmacophore modelling studies have been performed for a series of 2, 4-disubstituted-
pyrimidines derivatives as EGFR L858R/T790M tyrosine kinase inhibitors. The high scoring …
pyrimidines derivatives as EGFR L858R/T790M tyrosine kinase inhibitors. The high scoring …
Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer
R Han, H Guo, J Shi, S Zhao, Y Jia, X Liu, Y Liu… - BMC medicine, 2024 - Springer
Background Osimertinib has become standard care for epidermal growth factor receptor
(EGFR)-positive non-small cell lung cancer (NSCLC) patients whereas drug resistance …
(EGFR)-positive non-small cell lung cancer (NSCLC) patients whereas drug resistance …
Indole derivatives as new structural class of potent and antiproliferative inhibitors of monocarboxylate transporter 1 (MCT1; SLC16A1)
The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a
promising target for the treatment of cancer; however, the MCT1 modulator landscape is …
promising target for the treatment of cancer; however, the MCT1 modulator landscape is …
Late-stage modification of complex drug: base-controlled Pd-catalyzed regioselective synthesis and bioactivity of arylated osimertinibs
R Feng, YQ Zhen, D Wu, L Sun, JB Xu, X Li… - Science …, 2024 - science.org
Achieving regioselective synthesis in complex molecules with multiple reactive sites remains
a tremendous challenge in synthetic chemistry. Regiodivergent palladium-catalyzed C─ H …
a tremendous challenge in synthetic chemistry. Regiodivergent palladium-catalyzed C─ H …