Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

First variants of the Klebsiella pneumoniae carbapenemase (KPC), KPC-2 and KPC-3, have
encountered a worldwide success, particularly in K. pneumoniae isolates. These beta …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported
as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly
observed in human but also in veterinary medicine worldwide. E. coli is intrinsically …

Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …