Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by
motor and cognitive impairments, involving striatum, cortex and hippocampus. Synaptic and …

Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant HTT gene
expansions of CAG triplet repeat numbers that are inherited in an autosomal dominant …

Learning and memory deficits are early clinical manifestations of Huntington's disease (HD).
These cognitive impairments have been mainly associated with frontostriatal HD pathology; …

With predictive testing allowing the identification of gene-positive individuals prior to disease
onset, the prodromal stage of Huntington's disease provides an ideal period for the use of …

Objective Determining the sequence in which Huntington's disease biomarkers become
abnormal can provide important insights into the disease progression and a quantitative tool …

Affective disorders, such as anxiety and depression, are common comorbidities associated
with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these …

Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …

Synaptic plasticity is widely regarded as a putative biological substrate for learning and
memory processes. While both decreases and increases in synaptic strength are seen as …