[HTML][HTML] Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach

TA Zughaibi, M Suhail, M Tarique, S Tabrez - International Journal of …, 2021 - mdpi.com
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …

Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy's Potential in Prevention of Cell Damage, Cancer …

BR Yasin, HAN El-Fawal, SA Mousa - International journal of molecular …, 2015 - mdpi.com
This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date
palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its …

A randomized clinical trial evaluating the efficacy of an anthocyanin–maqui berry extract (Delphinol®) on oxidative stress biomarkers

S Davinelli, JC Bertoglio, A Zarrelli, R Pina… - Journal of the …, 2015 - Taylor & Francis
Objective: Berries are a rich source of anthocyanins, and clinical data suggest that a
polyphenol-rich diet may exert health-promoting effects by reducing oxidative stress. The …

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

S Rigacci, C Miceli, C Nediani, A Berti, R Cascella… - …, 2015 - pmc.ncbi.nlm.nih.gov
The healthy effects of plant polyphenols, some of which characterize the so-called
Mediterranean diet, have been shown to arise from epigenetic and biological modifications …

The gastrointestinal tract as a key target organ for the health-promoting effects of dietary proanthocyanidins

MJ Cires, X Wong, C Carrasco-Pozo… - Frontiers in nutrition, 2017 - frontiersin.org
Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods
and beverages widely consumed in the human diet. There is increasing evidence …

[HTML][HTML] Hydroxytyrosol exerts anti-inflammatory and anti-oxidant activities in a mouse model of systemic inflammation

R Fuccelli, R Fabiani, P Rosignoli - Molecules, 2018 - mdpi.com
Hydroxytyrosol (3, 4-dihydroxyphenil-ethanol, HT), the major phenol derived from olive oil
consumption, has shown different anti-inflammatory and anti-oxidant activities in vitro which …

Bioavailability of polyphenols and flavonoids in the era of precision medicine

M Hu, B Wu, Z Liu - Molecular Pharmaceutics, 2017 - ACS Publications
Ten years ago, Molecular Pharmaceutics (Volume 4, issue 6) published a special issue
devoted to bioavailability of flavonoids and polyphenols. At that time, many of the mysteries …

Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin …

X Wong, C Carrasco-Pozo, E Escobar… - Journal of Agricultural …, 2016 - ACS Publications
The protective effect of proanthocyanidin-containing polyphenol extracts from apples,
avocados, cranberries, grapes, or proanthocyanidin microbial metabolites was evaluated in …

Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities

MM Gravandi, S Fakhri, SN Zarneshan… - Metabolic brain …, 2021 - Springer
As progressive, chronic, incurable and common reasons for disability and death,
neurodegenerative diseases (NDDs) are significant threats to human health. Besides, the …

The extraction efficiency enhancement of polyphenols from Ulmus pumila L. barks by trienzyme-assisted extraction

Z Zhou, H Shao, X Han, K Wang, C Gong… - Industrial Crops and …, 2017 - Elsevier
This study aimed to optimize trienzyme-assisted extraction (EAE) conditions for total
polyphenols (TP) from Ulmus pumila barks (UPB). Response surface methodology (RSM) …