Ninhydrin adducts as valid synthon in organic synthesis: a review

S Das, A Dutta - ChemistrySelect, 2020 - Wiley Online Library
Abstract Ninhydrin (1, 2, 3‐indanetrione hydrate) is a powerful electrophile having
enormousapplications in organic and bio‐organic sciences. In the last few years, reactivity of …

[PDF][PDF] Ninhydrin in synthesis of heterocyclic compounds.

GM Ziarani, N Lashgari, F Azimian… - … : Online Journal of …, 2015 - academia.edu
Ninhydrin has been utilized in many heterocyclic preparations and considered as an
important building block in organic synthesis. There is a wide range of reactions that include …

Ninhydrin revisited: Quantitative chirality recognition of amines and amino alcohols based on nondestructive dynamic covalent chemistry

SL Pilicer, C Wolf - The Journal of Organic Chemistry, 2020 - ACS Publications
A novel approach to chiral recognition of small molecules using the classical ninhydrin
agent is introduced. Well-defined dynamic covalent chemistry with amines and amino …

The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the ortho selectivity of ninhydrin-phenol adducts

S Das, S Maity, P Ghosh, A Dutta - Synthetic Communications, 2021 - Taylor & Francis
Although ninhydrin is an essential analytical tool in biochemical and forensic sciences, for
the past several years, it has been employed as efficient building block for diverse organic …

Synthesis of flubromazepam positional isomers for forensic analysis

ES Ligon, J Nawyn, LV Jones, BMK Allred… - The Journal of …, 2019 - ACS Publications
Designer benzodiazepines have recently appeared in many forensic cases as legal
alternatives to federally scheduled drugs such as diazepam (Valium) and alprazolam …

New and efficient one-pot method for the synthesis of spiro [indoline-2, 1′-isobenzofuran] derivatives and evaluation of their anticancer activity by in vitro and in silico …

M Alborz, MR Mohammadizadeh, P Mardaneh… - Journal of Molecular …, 2025 - Elsevier
Novel anti-cancer agents are much needed to expand the available pharmacological tools
for patients suffering from this deadly disease. In this study, a series of 3′ H-spiro [indoline …

[HTML][HTML] Mechanochemical reaction of ninhydrin with aromatics, enols and amines: Synthesis, crystal structure and supramolecular self-assembly of cyclic and acyclic …

S Das, P Das, S Maity, P Ghosh, A Dutta - Results in Chemistry, 2023 - Elsevier
Ninhydrin and related indanone scaffolds are employed as effective synthon in organic and
bioorganic chemistry. In the present work, the reactivity of ninhydrin is exploited to …

Diastereo-and regioselective petasis aryl and allyl boration of ninhydrins towards synthesis of functionalized indene-diones and dihydrobenzoindeno-oxazin-ones

A Sengupta, S Maity, P Saha, P Ghosh, S Rudra… - Molecular Diversity, 2023 - Springer
Petasis aryl and allyl borations were accomplished using substituted ninhydrins, boronic
acids or 2-allyl-4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane and 1, 2-aminophenols in …

[PDF][PDF] Synthetic applications of 2-diazo-1, 3-indanedione

RE Khidre, IAM Radini, MS Mostafa… - Indian J. Heterocycl …, 2019 - jazanu.edu.sa
Synthetic Applications of 2-diazo-1,3-indanedione Page 1 Synthetic Applications of 2-diazo-1,3-indanedione
Rizk E. Khidre1,2*, Ibrahim Ali M. Radini2, Mohamed S. Mostafa2, Tahah A. Ameen2,3 …

Synthesis and Antimicrobial Action of Ninhydrin, Isatin, and 5-Acetyl-4-Hydroxy-1, 3-Thiazine-2, 6-Dione Derivatives Against Staphylococcus aureus and …

AS Zukhairaeva, AV Velikorodov, LV Saroyants… - Pharmaceutical …, 2022 - Springer
Series of new derivatives of ninhydrin, isatin, and 4-hydroxy-1, 3-thiazine-2, 6-dione were
synthesized. Their antimicrobial activity against opportunistic microflora of Staphylococcus …