Enhancing sepsis biomarker development: key considerations from public and private perspectives
JF Llitjos, ED Carrol, MF Osuchowski, M Bonneville… - Critical Care, 2024 - Springer
Implementation of biomarkers in sepsis and septic shock in emergency situations, remains
highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to …
highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to …
Artificial intelligence-driven drug development against autoimmune diseases
P Moingeon - Trends in pharmacological sciences, 2023 - cell.com
Artificial intelligence (AI)-based predictive models are being used to foster a precision
medicine approach to treat complex chronic diseases such as autoimmune and …
medicine approach to treat complex chronic diseases such as autoimmune and …
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …
Harnessing large language models (LLMs) for candidate gene prioritization and selection
Background Feature selection is a critical step for translating advances afforded by systems-
scale molecular profiling into actionable clinical insights. While data-driven methods are …
scale molecular profiling into actionable clinical insights. While data-driven methods are …
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
Knowledge of the mechanisms underpinning the development of protective immunity
conferred by mRNA vaccines is fragmentary. Here, we investigated responses to …
conferred by mRNA vaccines is fragmentary. Here, we investigated responses to …
MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus
XW Meng, ZL Cheng, ZY Lu, YN Tan, XY Jia… - Frontiers in …, 2022 - frontiersin.org
Background Systemic lupus erythematosus (SLE) is an autoimmune disease that involves
multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity …
multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity …
Identification and clinical validation of hypoxia-inducible factor 1α protein as the potential biomarker in patients with sepsis
H Ruan, Y Li, Q Zhang, B Wang, R Wu, S Li, X Ran - Shock, 2023 - journals.lww.com
Objective: Sepsis is a complex disease characterized by an inflammatory response and
tissue hypoxia. Hypoxia-inducible factor 1α (HIF-1α) expression level is regulated by …
tissue hypoxia. Hypoxia-inducible factor 1α (HIF-1α) expression level is regulated by …
Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia
SB Anyona, Q Cheng, SA Wasena, SW Osata… - Nature …, 2024 - nature.com
This study on severe malarial anemia (SMA: Hb< 6.0 g/dL), a leading global cause of
childhood morbidity and mortality, compares the entire expressed whole blood host …
childhood morbidity and mortality, compares the entire expressed whole blood host …
Human-augmented large language model-driven selection of glutathione peroxidase 4 as a candidate blood transcriptional biomarker for circulating erythroid cells
The identification of optimal candidate genes from large-scale blood transcriptomic data is
crucial for develo** targeted assays to monitor immune responses. Here, we introduce a …
crucial for develo** targeted assays to monitor immune responses. Here, we introduce a …