Understanding the Lymphatic System: Tissue-on-Chip Modeling
The lymphatic vasculature plays critical roles in maintaining fluid homeostasis, transporting
lipid, and facilitating immune surveillance. A growing body of work has identified lymphatic …
lipid, and facilitating immune surveillance. A growing body of work has identified lymphatic …
[HTML][HTML] Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication
Cancer progression is significantly influenced by the complex interactions within the tumor
microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors …
microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors …
Multi-parameter tunable synthetic matrix for engineering lymphatic vessels
Controlling the formation of new lymphatic vessels has been postulated as an innovative
therapeutic strategy for various disease phenotypes, including neurodegenerative diseases …
therapeutic strategy for various disease phenotypes, including neurodegenerative diseases …
A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation
S Kraus, E Lee - Lab on a Chip, 2023 - pubs.rsc.org
Interstitial fluid uptake and retention by lymphatic vessels (LVs) play a role in maintaining
interstitial fluid homeostasis. While it is well-established that intraluminal lymphatic valves in …
interstitial fluid homeostasis. While it is well-established that intraluminal lymphatic valves in …
Three-Dimensional Lymphatics-on-a-Chip Reveals Distinct, Size-Dependent Nanoparticle Transport Mechanisms in Lymphatic Drug Delivery
Although nanoparticle-based lymphatic drug delivery systems promise better treatment of
cancer, infectious disease, and immune disease, their clinical translations are limited by low …
cancer, infectious disease, and immune disease, their clinical translations are limited by low …
[HTML][HTML] Mimicking blood and lymphatic vasculatures using microfluidic systems
The role of the circulatory system, containing the blood and lymphatic vasculatures, within
the body, has become increasingly focused on by researchers as dysfunction of either of the …
the body, has become increasingly focused on by researchers as dysfunction of either of the …
The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models
The conception of vascularized organ-on-a-chip models provides researchers with the
ability to supply controlled biological and physical cues that simulate the in vivo dynamic …
ability to supply controlled biological and physical cues that simulate the in vivo dynamic …
Engineering Lymphangiogenesis‐On‐Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow
Despite the crucial role of lymphangiogenesis during development and in several diseases
with implications for tissue regeneration, immunity, and cancer, there are significantly fewer …
with implications for tissue regeneration, immunity, and cancer, there are significantly fewer …
[HTML][HTML] Advances in Ophthalmic Organ-on-a-Chip Models: Bridging Translational Gaps in Disease Modeling and Drug Screening
R Lu - International Journal of Translational Medicine, 2024 - mdpi.com
Background: Organ-on-a-chip models have emerged as transformative tools in
ophthalmology, offering physiologically relevant platforms for studying ocular diseases and …
ophthalmology, offering physiologically relevant platforms for studying ocular diseases and …
MicroVasculoid‐Chip: A 3D Self‐Assembled Human Microcirculation‐on‐a‐Chip Model Reveals Enhanced Lymphangiogenic Lung Cancer‐Induced Vessel …
The microvasculature within the tumor microenvironment is crucial for the invasion and
dissemination of cancer cells throughout the body. Given its importance and dynamic …
dissemination of cancer cells throughout the body. Given its importance and dynamic …