Comparative transcriptomics in human and mouse

A Breschi, TR Gingeras, R Guigó - Nature Reviews Genetics, 2017 - nature.com
Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Introns: the functional benefits of introns in genomes

BS Jo, SS Choi - Genomics & informatics, 2015 - pmc.ncbi.nlm.nih.gov
The intron has been a big biological mystery since it was first discovered in several aspects.
First, all of the completely sequenced eukaryotes harbor introns in the genomic structure …

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

X Zhao, Y Yang, BF Sun, Y Shi, X Yang, W **ao… - Cell research, 2014 - nature.com
Abstract The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …

Evolutionary dynamics of gene and isoform regulation in Mammalian tissues

J Merkin, C Russell, P Chen, CB Burge - Science, 2012 - science.org
Most mammalian genes produce multiple distinct messenger RNAs through alternative
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …

Expansion of the eukaryotic proteome by alternative splicing

TW Nilsen, BR Graveley - Nature, 2010 - nature.com
The collection of components required to carry out the intricate processes involved in
generating and maintaining a living, breathing and, sometimes, thinking organism is …

Regulation of alternative splicing through coupling with transcription and chromatin structure

S Naftelberg, IE Schor, G Ast… - Annual review of …, 2015 - annualreviews.org
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

A Siepel, G Bejerano, JS Pedersen… - Genome …, 2005 - genome.cshlp.org
We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

Non-coding RNA

JS Mattick, IV Makunin - Human molecular genetics, 2006 - academic.oup.com
The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

Deciphering the splicing code

Y Barash, JA Calarco, W Gao, Q Pan, X Wang, O Shai… - Nature, 2010 - nature.com
Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a …

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

CJ David, JL Manley - Genes & development, 2010 - genesdev.cshlp.org
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …