Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Despite the growing number of publications in the field of implant dentistry, there are limited
studies to date investigating the biology and metabolism of bone healing around dental …

Bone fragility is a major health concern, as the increased risk of bone fractures has
devastating outcomes in terms of mortality, decreased autonomy, and healthcare costs …

Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

The premise that bones grow and remodel throughout life to adapt to their mechanical
enironment is often called Wolff's law. Wolff's law, however, is not always true, and in fact …

Chronic inflammation is a prominent feature of aging and of common age‐related diseases,
including atherosclerosis, cancer and periodontitis. This volume examines modifiable risk …

Aging decreases the human femur's fatigue resistance, impact energy absorption, and the
ability to withstand load. Changes in the osteocyte distribution and in their elemental …

Age-related bone loss and associated fracture risk are major problems in musculoskeletal
health. Osteocytes have emerged as key regulators of bone mass and as a therapeutic …

Bone is a complex, hierarchically organized organ system whose composition and structure
are closely related to, and in many ways controlled by, the functional demands made upon it …