The Natural Biotic Environment of Caenorhabditis elegans

H Schulenburg, MA Félix - Genetics, 2017 - academic.oup.com
Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Copy number variation in domestication

ZN Lye, MD Purugganan - Trends in Plant Science, 2019 - cell.com
Domesticated plants have long served as excellent models for studying evolution. Many
genes and mutations underlying important domestication traits have been identified, and …

Evolution of new enzymes by gene duplication and divergence

SD Copley - The FEBS journal, 2020 - Wiley Online Library
Thousands of new metabolic and regulatory enzymes have evolved by gene duplication and
divergence since the dawn of life. New enzyme activities often originate from promiscuous …

Neural networks enable efficient and accurate simulation-based inference of evolutionary parameters from adaptation dynamics

G Avecilla, JN Chuong, F Li, G Sherlock… - PLoS …, 2022 - journals.plos.org
The rate of adaptive evolution depends on the rate at which beneficial mutations are
introduced into a population and the fitness effects of those mutations. The rate of beneficial …

Duplication of a domestication locus neutralized a cryptic variant that caused a breeding barrier in tomato

S Soyk, ZH Lemmon, FJ Sedlazeck… - Nature plants, 2019 - nature.com
Genome editing technologies are being widely adopted in plant breeding. However, a
looming challenge of engineering desirable genetic variation in diverse genotypes is poor …

Experimental Evolution with Caenorhabditis Nematodes

H Teotónio, S Estes, PC Phillips, CF Baer - Genetics, 2017 - academic.oup.com
The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …

How enzyme promiscuity and horizontal gene transfer contribute to metabolic innovation

ME Glasner, DP Truong, BC Morse - The FEBS journal, 2020 - Wiley Online Library
Promiscuity is the coincidental ability of an enzyme to catalyze its native reaction and
additional reactions that are not biological functions in the same active site. Promiscuity …

The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications

BS Assogba, P Milesi, LS Djogbénou… - PLoS …, 2016 - journals.plos.org
Gene copy-number variations are widespread in natural populations, but investigating their
phenotypic consequences requires contemporary duplications under selection. Such …

The conservation of the germline multipotency program, from sponges to vertebrates: a step** stone to understanding the somatic and germline origins

L Fierro-Constaín, Q Schenkelaars… - Genome biology and …, 2017 - academic.oup.com
The germline definition in metazoans was first based on few bilaterian models. As a result,
gene function interpretations were often based on phenotypes observed in those models …

Gene copy number variations as signatures of adaptive evolution in the parthenogenetic, plant‐parasitic nematode Meloidogyne incognita

P Castagnone‐Sereno, K Mulet, EGJ Danchin… - Molecular …, 2019 - Wiley Online Library
Adaptation to changing environmental conditions represents a challenge to parthenogenetic
organisms, and until now, how phenotypic variants are generated in clones in response to …